Corpus Callosotomy Surgery in Turkey

Corpus Callosotomy Surgery in Turkey

Corpus Callosotomy in Turkey

Epilepsy is a chronic disorder of the central nervous system. Patients with epilepsy experience recurrent seizure episodes, which occur due to abnormally excessive electrical activity in brain cells. Epilepsy may develop as a result of one or more of the following factors:

  • Genetic factors
  • Brain tumors
  • Medical history of stroke or any cerebrovascular disease affecting the brain
  • Direct traumatic head injuries, especially due to accidents or falls
  • Perinatal brain injury in newborns, such as complicated labor leading to reduced oxygen and blood supply to the brain
  • Viral or bacterial infections affecting brain tissue, such as meningitis (inflammation of the membranes surrounding the brain), viral encephalitis, or HIV infection

It is important to note that epilepsy presents in various clinical forms due to different types of seizures. Symptoms may range from complete loss of consciousness during a seizure, to episodes where the patient remains conscious but stares blankly into space. Other patients may experience varying degrees of involuntary muscle jerks in the limbs, known as convulsions.

Epilepsy is not limited to occasional seizures. One of the most serious risks occurs during seizure episodes, where patients may fall and sustain injuries or fractures. Seizures may also occur while driving, operating machinery, swimming, or even during bathing, posing a significant threat to the patient’s life. Additionally, epilepsy is often associated with sleep disturbances and an increased risk of psychological disorders such as depression, anxiety, self-harm tendencies, and suicidal ideation.

Epilepsy is initially managed with pharmacological treatment aimed at stopping seizures or reducing their frequency. However, in some cases, antiepileptic medications fail to achieve adequate control, leading to consideration of alternative therapeutic options. In such cases, corpus callosotomy in Turkey emerges as an effective surgical treatment option for drug-resistant epilepsy, which will be discussed in detail in this article.

What is Corpus Callosotomy in Turkey

The corpus callosum is a bundle of nerve fibers in the brain responsible for communication and coordination between the two cerebral hemispheres, ensuring optimal cognitive and functional performance of the brain.

Scientific studies on epilepsy have shown that seizure activity often originates from a focal area in one hemisphere and then spreads to the other hemisphere through the corpus callosum. Based on this understanding, researchers concluded that the corpus callosum plays a key role in the spread and generalization of seizures. Therefore, its partial or complete surgical interruption can help reduce seizure propagation.

Accordingly, corpus callosotomy in Turkey is a neurosurgical procedure that involves partially or completely severing the corpus callosum to prevent the spread of epileptic seizures between the two brain hemispheres, thereby helping to control seizure activity.

Indications for Corpus Callosotomy in Turkey

Corpus callosotomy may be considered an effective treatment option in the following cases:

  • Frequent epileptic seizures that do not respond to medication
  • Generalized epilepsy affecting both hemispheres of the brain simultaneously
  • Patients whose seizures significantly impair quality of life

Advantages of Corpus Callosotomy in Turkey

This procedure offers several benefits, including:

  • Effective treatment for drug-resistant epilepsy
  • Improvement in overall quality of life
  • Increased patient independence in daily activities
  • Enhanced safety and reduced risk of injury during seizures
  • Restoration of the ability to perform previously restricted activities such as driving, swimming, or diving

Preoperative Preparation for Corpus Callosotomy in Turkey

To achieve optimal surgical outcomes, the following steps are recommended during the preparation phase:

  • Detailed consultation with the patient and family regarding surgical details and recovery expectations
  • Full review of the patient’s medication history
  • Discontinuation of blood-thinning medications such as aspirin, Clexane, or heparin before surgery
  • Comprehensive neurological evaluation to determine seizure type, severity, and frequency
  • Brain imaging studies such as CT scan and MRI
  • Electroencephalography (EEG) to record brain electrical activity and identify seizure foci

These evaluations help determine whether corpus callosotomy is the most appropriate treatment option.

Surgical Procedure of Corpus Callosotomy in Turkey

The procedure is typically performed as follows:

  • The patient is placed under general anesthesia after confirming stable vital signs
  • A precise incision is made in the scalp to access the skull
  • A circular section of the skull is removed using a surgical drill
  • The dura mater is exposed and gently retracted
  • The surgeon carefully separates brain hemispheres to access the corpus callosum
  • The corpus callosum is partially or completely severed
  • The dura mater and skull segment are repositioned
  • The scalp is closed using fine surgical sutures

Note: The procedure is performed using high-precision microsurgical techniques with specialized magnification tools to ensure accuracy and safety.

Recovery After Corpus Callosotomy in Turkey

  • Hospital stay of 2–4 days depending on the patient’s condition
  • Gradual return to normal activities within 4–6 weeks
  • Continued use of antiepileptic medications as prescribed
  • Immediate medical consultation if unusual symptoms occur or seizures increase
  • Proper scalp care to prevent infection during healing
  • Possible rehabilitation or physical therapy sessions

Risks and Complications of Corpus Callosotomy in Turkey

Although performed in advanced medical centers with experienced neurosurgical teams, some temporary side effects may occur:

  • Numbness or tingling of the scalp (temporary nerve irritation)
  • Nausea and headache due to temporary intracranial pressure changes
  • Mild and temporary memory or concentration difficulties (rare and usually reversible)

These effects are generally temporary and improve gradually over time.

Cost of Corpus Callosotomy in Turkey

Turkey offers advanced neurosurgical technologies at significantly lower costs compared to European Union countries and the United States.

The total cost varies depending on:

  • Preoperative diagnostic tests
  • Experience of the surgical team
  • Hospital equipment and facilities

Advantages of Performing Corpus Callosotomy in Turkey

Turkey is considered a leading destination for neurosurgery, particularly epilepsy surgery such as corpus callosotomy, due to the following reasons:

  • Highly experienced neurosurgeons
  • Advanced hospitals with modern medical equipment
  • High-quality healthcare at affordable costs
  • Short waiting times and efficient procedures
  • Use of international medical protocols
  • High success rates in epilepsy surgery

Frequently Asked Questions

How effective is corpus callosotomy in stopping epileptic seizures?

Clinical studies indicate that corpus callosotomy can achieve complete seizure control in approximately 75% of patients, representing a high success rate compared to other treatment options.

Notes on Corpus Callosotomy in Turkey

There are typically two stages of corpus callosotomy:

  • First stage: severing the anterior two-thirds of the corpus callosum while preserving the posterior portion to maintain visual interhemispheric communication
  • Second stage (if needed): severing the remaining posterior portion if seizure control is insufficient

 

  1. https://my.clevelandclinic.org/health/treatments/11546-corpus-callosotomy https://pmc.ncbi.nlm.nih.gov/articles/PMC8699754/ https://www.chop.edu/treatments/corpus-callosotomy-surgery https://www.gosh.nhs.uk/conditions-and-treatments/procedures-and-treatments/corpus-callosotomy/ https://www.sciencedirect.com/science/article/abs/pii/S1878875022000407 https://www.lgsfoundation.org/corpus-callosotomy/ https://www.chp.edu/our-services/brain/neurosurgery/epilepsy-surgery/types-of-surgery/corpus-callosotomy Asadi-Pooya, A. A., Sharan, A., Nei, M., & Sperling, M. R. (2008). Corpus callosotomy. Epilepsy & Behavior, 13(2), 271-278.‏ Uda, T., Kunihiro, N., Umaba, R., Koh, S., Kawashima, T., Ikeda, S., ... & Goto, T. (2021). Surgical aspects of corpus callosotomy. Brain Sciences, 11(12), 1608.‏ Wong, T. T., Kwan, S. Y., Chang, K. P., Hsiu-Mei, W., Yang, T. F., Chen, Y. S., & Yi-Yen, L. (2006). Corpus callosotomy in children. Child's Nervous System, 22(8), 999-1011.‏ Jea, A., Vachhrajani, S., Widjaja, E., Nilsson, D., Raybaud, C., Shroff, M., & Rutka, J. T. (2008). Corpus callosotomy in children and the disconnection syndromes: a review. Child's Nervous System, 24(6), 685-692.‏ Sunaga, S., Shimizu, H., & Sugano, H. (2009). Long-term follow-up of seizure outcomes after corpus callosotomy. Seizure, 18(2), 124-128.‏ Markosian, C., Patel, S., Kosach, S., Goodman, R. R., & Tomycz, L. D. (2022). Corpus callosotomy in the modern era: origins, efficacy, technical variations, complications, and indications. World Neurosurgery, 159, 146-155.‏ Tripathi, M., Maskara, P., Rangan, V. S., Mohindra, S., De Salles, A. A., & Kumar, N. (2021). Radiosurgical corpus callosotomy: a review of literature. World Neurosurgery, 145, 323-333.‏ Sood, S., Marupudi, N. I., Asano, E., Haridas, A., & Ham, S. D. (2015). Endoscopic corpus callosotomy and hemispherotomy. Journal of Neurosurgery: Pediatrics, 16(6), 681-686.

Share :